Research in:

biotechnology, biologics
and tissue engineering

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About us

Top Health, S.A.P.I. de C.V. (Top Health) was founded in 2013 as a result of the normal course of Corporate Group IMT by Eng. José Adán Ortega Blanco, a visionary and entrepreneurial man. The desire to enter the field of health through tissue engineering and create alternatives in the area of regenerative medicine, through the use of cell and tissue therapy, led him to form a multidisciplinary group of high-level professionals (doctors, chemists, engineers and administrative staff).

Top Health develops medical devices of human origin and tissue engineering for its application in therapies such as: bone defects, skin wounds and ophthalmological injuries, resulting in wellness and improvement in the quality of life of people.

MISSION

VISION

QUALITY POLICY

Cellular therapy

  • Immuno-modulatory capacity (regulation of the immune system)

  • Stimulation of reparative processes in the body at the molecular level.

  • Potential to migrate to other cell lineages

  • Promote tissue healing through local secretion of cytokines and growth factors.

  • Contribute to the regeneration of bone and cartilage tissues.

  • Rheumatology
  • Orthopedics and Traumatology
  • Aesthetic medicine

Mesenchymal Stem Cells isolation (MSC) and cultivation is performed using GMP (Good Manufacturing Practices) products and reagents completely free of animal components.

Advanced center of musculoskeletal tissue, amnions and skin

The Advanced Center of Musculoskeletal Tissue, Decellularized Blood Vessels, Skin, Amnions, and recently Collagen, has as its objective the processing, storage and distribution of medical implants of human origin that are sterile and safe, ready for their application in the treatment of various pathologies.

Is ruled by ethical, safety and quality policies in its processes in accordance with the guidelines of the Mexican Official Standard NOM-241-SSA1-2021.

It´s conformed by a multidisciplinary staff highly qualified in the areas of tissue engineering, molecular biology and immunology.

It has sanitary license No.15-TR-14-120-0002 authorized by COFEPRIS (Federal Commission for the Protection against Sanitary Risks).

ALLOGRAFT BIO IMPLANTS

LYOPHILIZED BIOLOGICALS 

CANCELLOUS BONE POWDER
CORTICO-CANCELLOUS BONE POWDER
CANCELLOUS BONE GRANULE
CORTICO-CANCELLOUS BONE GRANULE
CANCELLOUS BONE CHIP
CORTICO-CANCELLOUS BONE CHIP
CANCELLOUS BONE BLOCK
DEMINERALIZED BONE MATRIX
CORTICAL BONE STRIP
BICORTICAL BONE STRIP
TRICORTICAL BONE STRIP
BONE DIAPHYSIS OF FIBULA
BONE DIAPHYSIS OF ULNA
BONE DIAPHYSIS OF HUMERUS
BONE DIAPHYSIS OF RADIUS
BONE DIAPHYSIS OF FEMUR
BONE DIAPHYSIS OF TIBIA

FROZEN BIOLOGICALS

ACHILLES TENDON
ACHILLES HEMITENDON
ANTERIOR TIBIALIS TENDON
POSTERIOR TIBIALIS TENDON
PERONEAL TENDON
SEMITENDINOSUS TENDON
FLEXOR DIGITORUM COMMUNIS TENDON
GRACILIS TENDON
FEMORAL HEAD
CONDYLE

BIOSCAFF® H

BIOSCAFF® H is a porous matrix for neurosurgery applications. Its innovative manufacturing process allows for collagen isolation from different human tissues, as well as a precisely controlled chemical process for optimal crosslinking degree. BIOSCAFF® H is highly adherent and is available in different sizes to meet different surgery needs.

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Installations

The processing and CEyE areas have an ISO 7 Class 10,000 classification **, the input warehouses and tissue reception are unclassified controlled areas; however, it should be noted that all areas have sanitary finishes and controlled air in accordance with their classification.

*Biosecurity: Non-viable suspended particles > 0.5 mm/m33 up to 3,520 Viable particles up to 1 CFU/m33
**Biosecurity: Non-viable suspended particles > 0.5 mm/m33 up to 352,000 Viable particles up to 10 CFU/m33
  • Cleaning and cutting the tissue
  • Tissue lyophilization
  • Tissue conditioning
  • Bone demineralization
  • Amniotic membrane processing
  • Processing of meshed and laminar skin
  • Cell Culture area

It has specialized equipment for tissue processing, such as:
Freeze dryers, ISO 5 class 100* biological safety cabinets and freezing equipment for the temporary storage of tissue in process.

  • Autoclave
  • Drying oven
  • Water purification system (Milli-Q Integral Millipore)

Storage of musculoskeletal tissue

  • Ultra-Low Freezers
  • Freezers
  • Refrigerators

Finished products storage

  • Ultra-Low Freezers
  • Cryomed
  • Cryoplus

Supplies storage

  • 304L grade stainless steel furniture

Our Services

ADVANCED CENTER OF PROGENITOR OR STEM CELLS

Specialized consulting in:

• Consulting in tissue processing
• Training in cell handling
• Cell Culture areas
• Knowledge transfers
• Consulting for the internal transplant committee

CRYOPRESERVATION

Storage procedure after cell isolation, culture, expansion, and quality testing. The cells are cryopreserved in nitrogen at -150°C through specialized and gradual processes that prevent thermal shock, stress and cell apoptosis; this guarantees up to 90% of cell viability post-thawing, and intact activity.
Cryopreservation is the method that uses low temperatures (down to -196°C) in order to preserve the structures of viable cells intact. Cells are cryopreserved to avoid losses due to temperature changes, to minimize the risk of genetic changes, and to decrease possible contamination.
Top Health recommends the storage of MTCs on crio-preservación for a period not exceeding 5 years.

ADVANCED CENTER OF MUSCULOSKELETAL TISSUE, AMNIONS AND SKIN

Specialized consulting in:

• Consulting in tissue processing
Consulting in skin procuration
• Consulting in the management and use of bone tissue implants
• Consulting in the management and use of tendons and ligaments implants
• Consulting in the management and use of fascia lata implants
• Consulting in the management and use of amniotic membrane dressings
• Consulting in the management and use of skin dressings
• Consulting in the management and use of skin equivalents

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